Fig. 6: Analysis of extracellular FP and intracellular AP in cardiomyocytes recorded by Mix-MEA. | Microsystems & Nanoengineering

Fig. 6: Analysis of extracellular FP and intracellular AP in cardiomyocytes recorded by Mix-MEA.

From: Multi-sized microelectrode array coupled with micro-electroporation for effective recording of intracellular action potential

Fig. 6

a–h Statistical plots of (a) intracellular AP Vpp, (b) ratio of intracellular AP Vpp to extracellular FP Vpp, (c) extracellular FP SNR and intracellular AP SNR, (d) intracellular AP duration, (e) extracellular AP and intracellular AP beat frequency, (f) APD50 duration, (g) single cell AP signal ratio and (h) AP yield. i–m Radar plots of parameters under different microelectrode sizes (20, 50, 100, 200, and 400 μm) in MSMEA and Mix-MEA. n, o Heatmaps of parameters under different microelectrode sizes (20, 50, 100, 200, and 400 μm) in MSMEA and Mix-MEA. Statistical plots were analyzed for a sample size of n = 10 or 4 data per group and were expressed as mean ± sem. Significant differences were analyzed by one-way ANOVA, *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001; NS, not statistically significant

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