Fig. 10: Antibacterial applications of SNs in tissue engineering.
From: Data-driven visualization of silica-based nanobiomaterial dynamics for tissue regeneration
a Antimicrobial drug delivery. SNs act as carriers, releasing antimicrobial drugs directly into injured tissues and enhancing antibacterial effects through diffusion. b Development of collaborative antibacterial platforms utilizing SNs loaded with antimicrobial drugs. Step I: Modify the surface of SNs with chemical groups or metal particles. Step II: Incorporate natural antibacterial ingredients into SNs. Step III: Dope SNs with antibacterial metal ions. c Fabrication of dressings and scaffolds with antibacterial properties. Step I: Incorporation of hyaluronic acid-coated MSN and β-cyclodextrin into the hydrogel system for long-lasting antibacterial effects in wound dressings59. Step II: Creation of bioactive scaffolds through three-dimensional (3D) printing using MSN mixed with hydrogel as ink to promote bacteriostasis and osteogenesis60
