Fig. 12: Applications of silica nanoparticles (SNs) in wound healing.
From: Data-driven visualization of silica-based nanobiomaterial dynamics for tissue regeneration
a Hemostasis promotion: (I) MSN combined with tannic acid (TA) promotes vasoconstriction. (II) Coagulation factor IV stimulates fibrin production. (III) Silver (Ag) nanoparticles exhibit antibacterial activity. b Inflammation regulation: (I) MSN-delivering cerium oxide (CeO) nanoparticles neutralize ROS produced in tissue cells and secreted by inflammatory cells through the conversion of Ce3+ and Ce4+, inhibiting tissue cell aging and regulating inflammation at the molecular level. (II) Resveratrol-loaded MSN influences macrophage polarization and the secretion of anti-inflammatory factors, regulating inflammation at the cellular level. (III) A novel MSN composite membrane facilitates the drainage of excess inflammatory exudate, regulating inflammation at the tissue level. c Proliferation regulation: Astragalus-loaded MSN promotes endothelial cell proliferation and collagen production. d Tissue Remodeling Improvement: Fe-curcumin chelate-loaded MSN inhibits excessive fibroblast proliferation, preventing scarring
