Fig. 1: Overview of the combinatorial screening chip (C-chip).
From: High-throughput combinatorial screening of antiplatelet drugs for personalized medicine
a Fluorescent barcode drug droplets and platelet droplets with varying diameters were generated using microfluidics. The drugs were pre-mixed with different fluorescent markers. b Platelet droplets were loaded into the microwell array device and occupy the larger microwells, followed by the loading of drug droplets that occupy the smaller microwells. Each small microwell randomly captured one drug droplet. Through corona treatment, the droplets in each microwell unit were merged, enabling combinatorial drug treatment for platelets and fluorescent labeling. c Using a fluorescence microscope, the aggregation and dispersion of platelets were continuously observed and recorded, with real-time images captured for each area of the chip. Subsequently, decoding software was used to re-identify the platelets and calculate the anti-aggregation efficiency of platelets for each individual drug or drug combination
