Fig. 1
From: Quasimesenchymal phenotype predicts systemic metastasis in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma. Epithelial predominant (epithelial phenotype) pancreatic ductal adenocarcinoma (a and b). Hematoxylin and eosin stained section (a) and corresponding in situ hybridization stain (b) showing tumor cells exclusively expressing high-level epithelial markers. Epithelial loss (quasimesenchymal phenotype) c and d The tumor cells show loss of expression of epithelial markers (arrow) (d). Note the high expression of mesenchymal markers in the stromal compartment. Epithelial loss and mesenchymal gain (quasimesenchymal phenotype) (e and f). Note the tumor cells (arrow) show both red (epithelial markers) and blue (mesenchymal markers) signal. a, c, and e—hematoxylin and eosin stain. b, d, and f—in situ hybridization stain for epithelial and mesenchymal markers
