Fig. 2: sHDT associated with FL.
From: The mutational landscape of histiocytic sarcoma associated with lymphoid malignancy
a Histological features of FL grade 3B (H&E, original magnification ×40) and HS, biopsy composite with FL (left) and the sequenced biopsy at 7 months (right) (original magnification ×200). The FL is positive for PAX5 (original magnification ×100) and negative for CD68 (original magnification ×100). Both HS biopsies are negative for PAX5 (original magnification ×100) and positive for CD68, which is more focal in the biopsy at 7 months (original magnification ×100, left; original magnification ×200, right). b The FL and HS share identical clonal IG arrangements. c Comparison of the mutational profiles of clonally related FL and HS.
