Fig. 1: Summary of immunohistochemical (IHC) patterns and TP53 mutations in invasive squamous cell carcinoma and squamous in situ lesions of the vulva. | Modern Pathology

Fig. 1: Summary of immunohistochemical (IHC) patterns and TP53 mutations in invasive squamous cell carcinoma and squamous in situ lesions of the vulva.

From: Major p53 immunohistochemical patterns in in situ and invasive squamous cell carcinomas of the vulva and correlation with TP53 mutation status

Fig. 1

HPV human papillomavirus, C IHC consistent with TP53 mutation status, DC discordant, DVIN differentiated vulvar intraepithelial neoplasia, deVIL differentiated exophytic vulvar intraepithelial lesion, *DVIN morphologic appearance of deVIL but with sufficient nuclear atypia to upgrade to DVIN, UVIN high-grade squamous intraepithelial lesion/usual vulvar intraepithelial neoplasia, VSCC vulvar squamous cell carcinoma, VSCC(S) VSCC with sarcomatoid features, VC verrucous carcinoma, W weak, M moderate, S strong, H heterogeneous, N/A not applicable.

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