Fig. 4: Cases showing stronger p53 scattered patterns and weaker p53 basal overexpression patterns that can be confused with each other. | Modern Pathology

Fig. 4: Cases showing stronger p53 scattered patterns and weaker p53 basal overexpression patterns that can be confused with each other.

From: Major p53 immunohistochemical patterns in in situ and invasive squamous cell carcinomas of the vulva and correlation with TP53 mutation status

Fig. 4: Cases showing stronger p53 scattered patterns and weaker p53 basal overexpression patterns that can be confused with each other.

a TP53 wild-type vulvar invasive squamous cell carcinoma (VSCC) showing stronger scattered staining (Case 53); b VSCC harboring a TP53 missense mutation, showing areas of prototypical basal overexpression and other areas c with weaker staining (Case 20); d A TP53 wild-type differentiated exophytic vulvar intraepithelial lesion (deVIL) showing stronger scattered staining (Case 61); e Differentiated vulvar intraepithelial neoplasia (dVIN) harboring a TP53 missense mutation, with areas of basal overexpression and areas f with weaker staining (Case 20).

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