Fig. 2: E4 staining patterns in CIN lesions. | Modern Pathology

Fig. 2: E4 staining patterns in CIN lesions.

From: Characterization of cervical biopsies of women with HIV and HPV co-infection using p16ink4a, ki-67 and HPV E4 immunohistochemistry and DNA methylation

Fig. 2

a CIN1 lesion (ID45) with extensive E4 staining (score 2). Corresponding Ki-67 and p16 stainings showed Ki-67 positivity staining up to the lower one-third of the epithelium (score 1) and patchy p16 staining (score 0). Hypermethylation was found for three methylation markers. b CIN2 lesion (ID67) with extensive E4 staining (score 2). Corresponding Ki-67 and p16 stainings showed increased Ki-67 staining up to the lower two-third of the epithelium (score 2) and diffuse p16 staining up to the lower one-third (score 1) of the epithelium. Hypermethylation was found for three methylation markers. c CIN 3 lesion (ID90) with focal E4 staining (score 1). Corresponding Ki-67 and p16 stainings showed full thickness Ki-67 staining of the epithelium (score 3) and full thickness p16 staining of the epithelium (score 3). Hypermethylation was found for 3 methylation markers. ID numbers correspond with the ID numbers of Fig. 3.

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