Table 2 Distribution of CMS & Immunoscore for non-pedunculated T1 CRCs and comparison between T1 CRCs with and without poor differentiation, lymphovascular invasion, deep submucosal invasion and tumor budding (assessed in the subgroup, n = 223 patients).
CMSa | Immunoscoreb | ||||||
|---|---|---|---|---|---|---|---|
Classification for CMS or Immunoscore, n (%) | CMS1 (MSI) n = 16 (7.2) | CMS2/3 n = 203 (91) | CMS4 n = 4 (1.8) | p | I-low n = 53 (25) | I-high n = 159 (75) | p |
Location in colorectum | <0.0001* | 0.48 | |||||
Right-sided colon | 13 (20.0) | 50 (76.9) | 2 (3.1) | 12 (19.4) | 50 (80.6) | ||
Left-sided colon | 3 (2.5) | 117 (96.7) | 1 (0.8) | 31 (27.4) | 82 (72.6) | ||
Rectum | 0 (0) | 36 (97.3) | 1 (2.7) | 10 (27.0) | 27 (73.0) | ||
CMS vs. Immunoscore | – | 0.14 | |||||
CMS1, n = 15 | – | – | – | 1 (6.7) | 14 (93.3) | ||
CMS 2/3, n = 193 | – | – | – | 52 (26.9) | 141 (73.1) | ||
CMS 4, n = 4 | – | – | – | 0 (0) | 4 (100) | ||
Differentiation grade | 0.19 | 0.27 | |||||
Moderate/good, n = 167 | 15 (9.0) | 149 (89.2) | 3 (1.8) | 37 (23.1) | 123 (76.9) | ||
Poor, n = 54 | 1 (1.9) | 52 (96.3) | 1 (1.9) | 16 (31.4) | 35 (68.6) | ||
Lymphovascular invasion | 0.15 | 0.87 | |||||
Absent, n = 133 | 13 (9.8) | 117 (88.0) | 3 (2.3) | 31 (24.4) | 96 (75.6) | ||
Present, n = 87 | 3 (3.4) | 83 (95.4) | 1 (1.2) | 21 (25.6) | 61 (74.4) | ||
Submucosal invasion depth | 0.62 | 1.0 | |||||
Superficial, n = 23 | 1 (4.3) | 21 (91.3) | 1 (4.3) | 5 (22.7) | 17 (77.3) | ||
Deep, n = 176 | 13 (7.4) | 160 (90.9) | 3 (1.7) | 39 (23.4) | 128 (76.6) | ||
Tumor budding | 0.82 | 0.02 | |||||
Low-grade, n = 156 | 13 (8.3) | 140 (89.7) | 3 (1.9) | 30 (20.1) | 119 (79.9) | ||
High-grade, n = 57 | 3 (5.3) | 53 (93.0) | 1 (1.8) | 20 (37.7) | 33 (62.3) | ||
