Fig. 1: Mutation profile of recurrently mutated genes in the dMMR and pMMR CRCs. | Modern Pathology

Fig. 1: Mutation profile of recurrently mutated genes in the dMMR and pMMR CRCs.

From: Next-generation sequencing reveals heterogeneous genetic alterations in key signaling pathways of mismatch repair deficient colorectal carcinomas

Fig. 1

a Prevalence of most frequently mutated genes in the dMMR CRCs compared with that in the pMMR CRCs. b Prevalence of the most frequently mutated genes in the pMMR CRCs compared with that in the dMMR CRCs. c Fraction of MSI-related somatic mutations of the 20 most recurrently mutated tumor suppressor genes in the dMMR CRCs. d Bar chart showing the most commonly detected MSI-related genes in the dMMR CRCs. dMMR deficient mismatch repair, pMMR proficient mismatch repair, CRC colorectal carcinoma, MSI microsatellite instability. Asterisk (*) significant difference in mutation prevalence (Chi-square test or Fisher’s exact test, P < 0.05).

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