Fig. 5: Mutation profile of key genes in the dMMR and pMMR CRCs. | Modern Pathology

Fig. 5: Mutation profile of key genes in the dMMR and pMMR CRCs.

From: Next-generation sequencing reveals heterogeneous genetic alterations in key signaling pathways of mismatch repair deficient colorectal carcinomas

Fig. 5

Columns represent individual cases sorted by MMR status and dMMR subgroups. Tracks indicate dMMR status, MLH1 promoter hypermethylation status, MMR gene germline mutation status and RTK-RAS, PI3K, WNT, TGFβ, and TP53 pathway gene mutations. Individual genes are listed in rows. Mutations affecting tumor suppressor genes are classified according to whether they bear the MSI signature (insertions or deletions affecting homopolymer sequences). dMMR deficient mismatch repair, pMMR proficient mismatch repair, MSI microsatellite stability.

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