Fig. 1: TP53 immunohistochemistry staining patterns. | Modern Pathology

Fig. 1: TP53 immunohistochemistry staining patterns.

From: Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

Fig. 1: TP53 immunohistochemistry staining patterns.

a Normal pattern with heterogeneous nuclear staining in variable distribution. b Abnormal overexpression (OE) with virtually all viable tumor cell nuclei showing strong nuclear staining. c Abnormal complete absence with no nuclear staining of tumor cells but normal control staining in nontumor stromal or immune cells. d Abnormal cytoplasmic staining with unequivocal cytoplasmic staining and variable nuclear staining. e Mucinous borderline tumor with intratumoral heterogeneity or subclonal TP53 abnormal pattern. Inset: both normal (upper) and abnormal OE patterns (lower) are seen within the same tumor. Abnormal OE is seen in an area of mucinous intraepithelial carcinoma. In addition, the abnormal OE area displays terminal differentiation with the basal layer of cells demonstrating abnormal OE pattern staining with sparing of superficial areas.

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