Fig. 3: Voxelwise comparison of Striatal Dopamine Synthesis Capacity between groups. | Molecular Psychiatry

Fig. 3: Voxelwise comparison of Striatal Dopamine Synthesis Capacity between groups.

From: Striatal dopaminergic alterations in individuals with copy number variants at the 22q11.2 genetic locus and their implications for psychosis risk: a [18F]-DOPA PET study

Fig. 3: Voxelwise comparison of Striatal Dopamine Synthesis Capacity between groups.

A Regions of significantly higher striatal Kicer, relative to healthy controls (N = 26), in individuals with 22q11.2 deletion (N = 21). The most significant statistical increases had peaks in the left (peak MNI coordinates x = −24, y = 12, z = 4; puncorr = 0.001) and right putamen (peak MNI coordinates x = 28, y = 10, z = 4; puncorr = 0.016). B Regions of significantly higher striatal Kicer, relative to 22q11.2 duplication group (N = 11), in 22q11.2 deletion subjects (N = 21). The most significant increases had peaks in the right (peak MNI coordinates x = 28, y = 8, z = −6; puncorr = 0.002) and left putamen (peak MNI coordinates x = −28, y = 12, z = −6; puncorr = 0.003). C Regions of significantly lower striatal Kicer, relative to healthy controls (N = 26), in individuals with 22q11.2 duplication (N = 11). The most significant reductions had peaks in the left (peak MNI coordinates x = −12, y = 16, z = 12; p = 0.001) and right caudate nuclei (peak MNI coordinates x = 10, y = 14, z = 12; puncorr = 0.008). None of these voxel peaks survived correction for multiple comparisons using FWE. All maps refer to t-stats statistics threshold at p < 0.05 uncorrected.

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