Fig. 1: Chemical structures of Cilobradine, Ivabradine and Zatebradine and their analogs designed and synthesized to improve BBB permeability. | Molecular Psychiatry

Fig. 1: Chemical structures of Cilobradine, Ivabradine and Zatebradine and their analogs designed and synthesized to improve BBB permeability.

From: Design and validation of novel brain-penetrant HCN channel inhibitors to ameliorate social stress-induced susceptible phenotype

Fig. 1: Chemical structures of Cilobradine, Ivabradine and Zatebradine and their analogs designed and synthesized to improve BBB permeability.

a Structures of Cilobradine, Ivabradine and Zatebradine. b Novel analogs that are designed, synthesized and used in this study. Modifications to the substituents of the left-hand side phenyl ring are highlighted in blue. The alteration of the central piperidine ring of Cilobradine to a morpholine ring is represented by the introduced oxygen highlighted in orange. The replacement of the benzylic methylene group of Zatebradine with a difluoromethylene group is highlighted in pink.

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