Fig. 2: RO4938581 normalizes the paired-pulse ratio in both wildtype and 15q dup mice. | Molecular Psychiatry

Fig. 2: RO4938581 normalizes the paired-pulse ratio in both wildtype and 15q dup mice.

From: RO4938581, a GABAA-α5 negative allosteric modulator rescued behavioral and EEG phenotypes of a mouse model of Dup15q syndrome

Fig. 2: RO4938581 normalizes the paired-pulse ratio in both wildtype and 15q dup mice.

A Superimposed representative traces of population spikes recorded in the CA1 region of hippocampal brains slices of WT and 15q dup mice. The paired-pulse protocol consisted of two stimuli timely spaced by 20 ms applied to Schaffer collaterals. Dark traces were obtained in the presence of vehicle and light traces in the presence of RO4938581 at 0.3 μM. B Paired-pulse inhibition was first measured in the absence (vehicle) and then in the presence of 0.3 μM RO4938581 and expressed as the ratio of the amplitude of population spike recorded after the first of two stimuli (as represented in A; 15q dup n = 4 mice, 8 slices; WT n = 3 mice, 7 slices). Results are expressed as individual points (circles) and mean ± standard error of the mean. *** p = 0.0007 effect of RO4938581 in 15q dup slices; ** p = 0.0031 effect of RO4938581 in WT slices.

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