Fig. 4: RO4938581 partially normalizes increased beta-band activity in 15q dup mice.

A Power spectrum derived from 6-h continuous EEG recordings after vehicle dosing in wild type (WT; n = 8) and 15q dup (n = 6) mice during the awake state. B Ratio of spectrally-resolved power between 15q dup and WT mice shown in A. Black bar indicates significantly elevated power in the beta frequency range in 15q dup mice (~20−30 Hz; p = 0.017, cluster permutation test). C Changes in EEG power spectrum in response to diazepam (DZP) in WT mice. Diazepam increased the power in the beta to low gamma frequency range (~16−45 Hz; p = 0.007, cluster permutation test) and decreased it in the high gamma frequency range (~68−128 Hz, p = 0.015). D Changes in EEG power spectrum in response to RO4938581 (low and high doses combined) in 15q dup mice (left) and WT mice (right) in the frequency range of 20−30 Hz, i.e., focused on the frequency range of the 15q dup phenotype shown in (A). A significant decrease in power was observed in 15q dup mice after RO4938581 administration (~22.6−25.4 Hz; p = 0.030, cluster randomization test) but not in WT mice. CI = confidence interval. See Supplementary Fig. 7 for separate analyses for low and high doses of RO4938581 in 15q dup mice.