Fig. 2: Association between transdiagnostic genetic liabilities and cumulative disease burden from the quasi-Possion models.
Results are derived from quasi-Possion regression models based on 4028 AN cases with number of unique clinical diagnoses (any, psychiatric, somatic), prescriptions (any, antipsychotics, antidepressants) and inpatient days (any, due to EDs) as outcomes. For each of the eight outcomes, we constructed six models with PRSshared (A), PRSAN-specific (B), PRSOCS-specific (C), PRSMDD-specific (D), PRSSCZ-specific (E) and PRSANX-specific (F) as exposure variable, respectively. Incidence rate ratios indicate the risk estimates for +1 SD increase of PRS. Sex, birth year and first 10 ancestry-informative principal components were adjusted for in all models. The points represent incidence rate ratio estimates, and the error bars indicate 95% confidence intervals. Blue points represent effect estimates for clinical diagnoses, red points represent effects for medication prescriptions and yellow points represent effects for inpatient days. “*” represents association that remained significant after Bonferroni correction. “#” represents trending association at P < 0.05 but was not significant after Bonferroni correction. PRS polygenic risk scores, EDs eating disorders, IRR incidence rate ratio, 95%CI 95% confidence interval, AN anorexia nervosa, SCZ schizophrenia, OCS obsessive-compulsive symptoms, MDD major depressive disorder, ANX anxiety disorders.
