Table 3 Main regression models for all comers: cross-sectional associations between APOE e4 status and Moray House Test (MHT) scores at each age separately.

		Lothian Birth Cohort 1936 (N = 1010 at baseline age 70)
		Model 1 – age + sex					Model 2 – age + sex + health covariates
MHT	N	Std est	SE	P value	95% CI	N	Std est	SE	P value	95% CI
Age 11	954	0.005	0.032	0.884	−0.058, 0.067
Age 70	^a1001	−0.022	0.031	0.483	−0.083, 0.039	1001	−0.025	0.031	0.415	−0.086, 0.036
Age 76	636	−0.132	0.038	0.001	−0.207, −0.056	634	−0.132	0.038	0.001	−0.208, −0.057
Age 79	471	−0.161	0.044	<0.001	−0.248, −0.074	468	−0.157*	0.044	<0.001	−0.244, −0.070
		Lothian Birth Cohort 1921 (N = 539 at baseline age 79)
Age 11	483	−0.046	0.044	0.302	−0.153, 0.041
Age 79	^b533	−0.114	0.043	0.008	−0.197, −0.030	525	−0.112*	0.043	0.009	−0.196, −0.029
Age 87	198	−0.224	0.070	0.001	−0.362, −0.086	196	−0.231	0.069	0.001	−0.367, −0.095
Age 90	120	−0.296	0.088	0.001	−0.469, −0.123	120	−0.333	0.086	<0.001	−0.502, −0.165

^*The meta-analytic effect size across both cohorts at age 79 (adjusted model 2—see asterisked values above) is −0.134; SE = 0.031; P < 0.0001; 95%CI = −0.194, −0.074.
^aIn the LBC1936, N = 9 were missing a MHT score at older-age baseline age 70.
^bIn the LBC1921, N = 6 were missing an MHT score at older-age baseline age 79. The health covariates (yes/no) in model 2 are CVD, diabetes, stroke, and hypertension.
P values <0.05 are indicated in bold.

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