Table 4 Main regression models for completers only: cross-sectional associations between APOE e4 status and Moray House Test (MHT) scores at each age separately.

	Lothian Birth Cohort 1936 (N = 457)
		Model 1 – age + sex					Model 2 – age + sex + health covariates
MHT	N	Std est	SE	P value	95% CI	N	Std est	SE	P value	95% CI
Age 11	430	−0.046	0.047	0.330	−0.139, 0.047
Age 70	457	−0.080	0.046	0.081	−0.171, 0.010	457	−0.080	0.046	0.082	−0.172, 0.010
Age 76	457	−0.126	0.046	0.006	−0.216, −0.036	457	−0.126	0.046	0.006	−0.215, −0.036
Age 79	457	−0.161	0.045	<0.001	−0.249, −0.073	454	−0.160*	0.045	<0.001	−0.248, −0.071
	Lothian Birth Cohort 1921 (N = 119)
Age 11	104	−0.112	0.093	0.232	−0.294, 0.011
Age 79	119	−0.134	0.090	0.137	−0.311, 0.043	116	−0.141*	0.090	0.119	−0.318, −0.036
Age 87	119	−0.202	0.088	0.021	−0.374, −0.031	119	−0.202	0.088	0.022	−0.376, −0.029
Age 90	119	−0.289	0.082	<0.001	−0.451, −0.128	119	−0.312	0.081	<0.001	−0.471, −0.153

Completers are those who attended, and sat the MHT, at all 3 waves in later life. The health covariates in model 2 are CVD, diabetes, stroke, and hypertension (yes/no).
*The meta-analytic effect size across both cohorts at age 79 (adjusted model 2–see asterisked values above) is -−0.156; SE = 0.040; P = 0.0001; 95%CI = −0.235, −0.077.
P values <0.05 are indicated in bold.

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