Table 5 Longitudinal growth models: associations of APOE e4 with change in Moray House Test (MHT) score across later life (fully-adjusted).

From: Effect sizes of APOE e4 on the same general cognitive ability test taken by the same people from age 11 to age 90: The Lothian Birth Cohorts 1921 and 1936

 

Lothian Birth Cohort 1936 (N = 1010 at baseline)

 

Intercept (APOE e4 and MHT at baseline, age 70)

Slope (APOE e4 and MHT change from age 70–79)

Predictors

Std est

SE

P value

95% CI

Std est

SE

P value

95% CI

APOE e4

−0.031

0.032

0.331

−0.094, 0.032

−0.221

0.056

<0.001

−0.330, −0.112

CFI

1.00

 

RMSEA

0.00

SRMR

0.00

 

Lothian Birth Cohort 1921 (N = 539 at baseline)

 

Intercept (APOE e4 and MHT at baseline, age 79)

Slope (APOE e4 and MHT change from age 79–90)

APOE e4

−0.112

0.044

0.010

−0.197, −0.027

−0.309

0.080

<0.001

−0.467, −0.151

CFI

0.95

 

RMSEA

0.06

SRMR

0.03

  1. The growth curve model for each cohort is fully-adjusted for all wave 1 covariates: age; sex; CVD; stroke; high blood pressure; diabetes. Slope values are based on change in Moray House Test score from age 70 to age 79 (for LBC1936) and from age 79 to age 90 (for LBC1921). Model fit was tested using absolute fit indices: Comparative Fit Index (CFI; values > 0.95 considered acceptable), Root Mean Square Error of Approximation (RMSEA; values < 0.06 considered acceptable), and Standardized Root Mean Square Residual (SRMR; values < 0.08 considered acceptable).
  2. P values <0.05 are indicated in bold.
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