Fig. 3: Network distinctiveness was higher in frontal and temporal SA communities and lower in a frontal CT community in CHR-T versus CHR-NT.

A Nine identified communities (colours) projected to surface (cortical regions) or structural image (subcortical regions). Among others, SA and CT of occipital and sensorimotor areas, and subcortical brain volumes, were grouped together into the same communities. Separate SA and CT communities were identified for temporal and frontal regions. B Bar charts (with standard errors) visualizing higher frontal and temporal SA system segregation index, and lower frontal CT community segregation index in CHR-T versus CHR-NT (FDR-corrected across 9 communities). Horizontal bar with * indicates significant group difference after FDR correction (q < 0.05). C mean structural covariance matrix for healthy controls (left), CHR-NT (middle) and CHR-T individuals (right). Rows and columns were grouped according to the 9 communities. The colour bars on the left and the bottom of each matrix and the colour boxes along the diagonal of each matrix indicate the community following the same colour scheme in Fig. 3A. Within each matrix, the colours indicate the covariance strength, with the lowest in blue and the highest in red. CHR-T individuals at clinical high risk for psychosis who transited to psychosis later in the follow-up; CHR-NT individuals at clinical high risk for psychosis who did not transit to psychosis later in the follow-up; CT cortical thickness; SA cortical surface area; q FDR corrected p value; FDR false discovery rate.