Fig. 3: In vivo assays: HTR, change in body temperature and HLA. | Molecular Psychiatry

Fig. 3: In vivo assays: HTR, change in body temperature and HLA.

From: Neuropharmacology of halogenated DMT analogs: psychoplastogenic and antidepressant properties of 5-Br-DMT, a psychedelic derivative with low hallucinogenic potential

Fig. 3

A-D Number of head twitch events during a 10-min period upon i.p. administration of DMT, 5-F-DMT, 5-Cl-DMT and 5-Br-DMT. N = 10 mice/group. E Pearson correlation (p < 0.05, R2 = 0.0313) between calcium mobilization potency (EC50) and HTR maximal effects. F Pearson correlation (p < 0.01, R2 = 9835) between the ratio EC50 (Ca2+ mobilization)/EC50 (cAMP accumulation inhibition) and HTR potency (ED50). G Scored head twitches in 10 min upon administration of 5-Br-DMT (10 mg/kg, i.p.), 5-F-DMT (1 mg/kg, i.p.), or 5-Br-DMT (10 mg/kg, i.p.) pretreatment followed by 5-F-DMT (1 mg/kg, i.p.). N = 7 mice/group. H-K Change in core body temperature 60 min after injection. L-O Total distance traveled in a 30-min period following i.p. administration. N = 10 mice/group. Data are presented as means ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 vs. control group (One-way ANOVA followed by Dunnett’s test or Kruskal-Wallis followed by Dunn’s test).

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