Fig. 3: CPP, self-administration and microdialysis. | Molecular Psychiatry

Fig. 3: CPP, self-administration and microdialysis.

From: The psychedelic phenethylamine 25C-NBF, a selective 5-HT2A agonist, shows psychoplastogenic properties and rapid antidepressant effects in male rodents

Fig. 3

Effects of 25C-NBF (A), 25B-NBF (B) and 25I-NBF (C) on the CPP test in mice, and graphical representation of the CPP test (D). Bars represent the mean ± SD of the preference score (difference between the time spent in the drug-paired compartment on the test day and the preconditioning day), (ANOVA). n = 10–12/group. Self-administration of different phenethylamines in rats trained to self-administer methamphetamine (E), and graphical representation of the self-administration experiment (F). Number of single press on the active lever by different cohorts of rats after establishing a baseline of self-administration with methamphetamine (50 μg/kg/inj), which was then substituted with 25C-NBF (100 μg/kg/inj), 25B-NBF (100 μg/kg/inj), 25I-NBF (100 μg/kg/inj), or their vehicle (1% DMSO in sterile saline) for five 2 h sessions. (Two-way ANOVA). n = 7–8/group. Extracellular levels of DA (G) in the NAcc of awake rats treated with NBFs (3 mg/kg s.c.) (mixed effects model, n = 4–6/group), and schematic illustration of the probe placement in the NAcc of a rat (H). Images source: images adapted and/or modified from Servier Medical Art, CC BY 3.0, via https://smart.servier.com (D,F) and from the Rat Brain Atlas by Gaidica [88] (H).

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