Fig. 1: Putative neurocircuitry of PD and clinical anxiety. | Molecular Psychiatry

Fig. 1: Putative neurocircuitry of PD and clinical anxiety.

From: Structural brain differences associated with panic disorder: an ENIGMA-Anxiety Working Group mega-analysis of 4924 individuals worldwide

Fig. 1

Anomalies within these regions tend to collectively impede how emotionally salient information is perceived, processed, and modulated. This includes brain areas involved in sensory processing (occipital cortex, fusiform gyrus, thalamus; green), emotion generation and processing (striatum, amygdala, insula, dorsal anterior cingulate cortex; red) and emotion modulation (medial prefrontal cortex, hippocampus, dorsolateral prefrontal cortex, subgenual/rostral anterior cingulate cortex; blue). Adapted and reprinted with permission from Wiley Periodicals, Inc.: Human Brain Mapping (Bas-Hogendam et al., [1]). Amy Amygdala, Cau, Nucleus Caudatus, Hip Hippocampus; NAcc, Nucleus Accumbens, Pa Pallidum, Pu Putamen, Tha Thalamus, CAcc Caudal Anterior Cingulate Cortex, FF Fusiform, INS Insula, LOC Lateral Occipital, MOF Medial Orbitofrontal, RAcc Rostral Anterior Cingulate Cortex, RMF Rostral Middle Frontal, SF Superior Frontal.

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