Fig. 1: Study Design. | Molecular Psychiatry

Fig. 1: Study Design.

From: Delay discounting correlates with depression but does not predict relapse after antidepressant discontinuation

Fig. 1

We recruited remitted patients treated with antidepressant medication (ADM) and healthy controls matched for age, sex and education to the patients group. Patients were assessed at Main Assessment 1 (MA1) to identify features characterizing the remitted, medicated state. Next, patients were randomized to either discontinue their medication before MA2 (bottom arm, “group MA-1-D-MA2” or enter a waiting period while continuing their ADM, matched to the length of discontinuation time (top arm, “group MA1-MA2-D”). Discounting was assessed at MA1 and MA2, to investigate the effects of discontinuation. Patients in the MA1-MA2-D discontinued their ADM after MA2. After discontinuation, all patients entered the follow-up (FU) period of 6 months, during which some patients relapsed. Numbers below each box indicate the number of subjects in that group. The numbers below each box indicate the number of subjects in the corresponding group.

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