Fig. 3: Effect sizes for group differences in log K.

Cohen’s d effect size, for various group comparisons. The top bar shows the comparison of log K at MA1 between controls and patients, where the effect size in this case indicates that the average of log K in the Patients group (at both sites) at MA1 is greater than the average of log K in the Controls group at MA1. The second bar from above shows the comparison of log K at MA1 between patients who subsequently relapsed and patients who did not, where the effect size in this case indicates that the average of log K in non-relapsers at MA1 is greater than the average of log K in relapsers at MA1. The third bar shows the comparison of the change in log K between the two timepoints (gain scores), between patients who discontinued their treatment at MA1 (MA1-D-MA2) and patients who continued their treatment until MA2 (MA1-MA2-D), where the effect size indicates that the average of gain scores in the MA1-D-MA2 group is greater than the average of gain scores in the MA1-MA2-D group. The bottom bar shows the comparison of the change in log K between the two timepoints (gain scores), between patients from the MA1-D-MA2 group who subsequently relapsed and patients from the MA1-D-MA2 group who did not, where the effect size indicates that the average of gain scores in the non-relapsers group was greater than the average of gain scores in the relapsers group. Error bars represent 95% confidence interval for Cohen’s d effect size, estimated using MATLAB meanEffectSize function. Group difference p-value: * 0.01<p < 0.05.