Fig. 2: eEF2K overexpression increased apathy-like behavior. | Molecular Psychiatry

Fig. 2: eEF2K overexpression increased apathy-like behavior.

From: Overactive Neuronal eEF2K/eEF2 signaling is associated with cognitive impairment and apathy-like behavior

Fig. 2: eEF2K overexpression increased apathy-like behavior.

(A) The percent of nestlet shredded in a 30 min period was decreased in the eEF2K-cKI mice. Cre, n = 10; eEF2K-cKI, n = 11. p = 0.0060. (B) Representative images of nests for nest score (C) Nest building score was decreased in the eEF2K-cKI mice. Cre, n = 10; eEF2K-cKI, n = 11. p = 0.0047. (D) The percent of nestlet left unshredded during the nest building task was increased in the eEF2K-cKI mice. Cre, n = 10; eEF2K-cKI, n = 11. p = 0.0160. (E) The number of marbles buried in a 30 min period was decreased in the eEF2K-cKI mice. Cre, n = 10; eEF2K-cKI, n = 11. p = 0.0017. (F) There was no difference in the percent burrowed in the 2 hr burrowing task. Cre, n = 10; eEF2K-cKI, n = 11. p = 0.4232. (G) There was no difference in the percent burrowed in the overnight burrowing task. Cre, n = 10; eEF2K-cKI, n = 11. p = 0.1077. (H) The eEF2K-cKI mice had significantly higher combined apathy z-score compared to cre controls. Cre, n = 10; eEF2K-cKI, n = 11. p = 0.0003. Error bars represent ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001; Student’s T-test.

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