Fig. 2: Heterogeneous individual deviations from normative models in subthreshold depression and deviation-based subtypes. | Molecular Psychiatry

Fig. 2: Heterogeneous individual deviations from normative models in subthreshold depression and deviation-based subtypes.

From: Connectome-based growth models reveal individual heterogeneity and neurophysiological subtypes of subthreshold depression

Fig. 2: Heterogeneous individual deviations from normative models in subthreshold depression and deviation-based subtypes.

a Distribution of the number of brain regions per StD participant showing extreme positive (red) and negative (blue) deviations. b Spatial overlap maps showing the percentage of StD participants with extreme deviations from the normative range in each brain region (left, extreme positive deviations; right, extreme negative deviations). c Determination of the optimal number of StD subtypes via the NbClust package and the intersubject similarity in FCS deviation patterns among all participants with StD. d Mean deviation maps for each subtype and their system-level differences. e Subtype differences in overall deviation indices. f Subtype differences in clinical manifestations. StD subthreshold depression, VIS visual network, SMN sensorimotor network, DAN dorsal attention network, VAN ventral attention network, LIM limbic network, FPN frontoparietal network, DMN default mode network, SUB subcortical regions, HDRS Hamilton Depression Rating Scale. *p < 0.05; **FDR-corrected q < 0.05.

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