Fig. 3: Associations between the brain deviation map of subtype 1 and gene expression profiles. | Molecular Psychiatry

Fig. 3: Associations between the brain deviation map of subtype 1 and gene expression profiles.

From: Connectome-based growth models reveal individual heterogeneity and neurophysiological subtypes of subthreshold depression

Fig. 3: Associations between the brain deviation map of subtype 1 and gene expression profiles.

a Explained ratios for the first 10 components obtained from the partial least squares (PLS) regression analysis, with the significant PLS component marked by an asterisk. b Spatial patterns illustrating the mean deviation map of subtype 1 and the first PLS component (PLS1) scores in the left hemisphere. The deviation values are positively correlated with the PLS scores (10,000 permutation tests with spatial autocorrelation correction). The shaded area represents the 95% confidence interval. Each dot corresponds to a region. (c,d) Functional enrichment of the top-ranked PLS+ (c) and PLS- genes (d). Left: top ten ontology terms for PLS+ and PLS- genes, the size of the circles represents the number of genes involved in a given term. Right: Metascape enrichment network visualization depicting intra-cluster and inter-cluster similarities among enriched terms. Each term is represented by a circular node, with size proportional to the number of input genes included, and nodes of the same color belong to the same cluster. BP, biological processes; CC, cellular components; MF, molecular functions.

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