Table 2 Ten upregulated DEGs only shared between Sh3^+/−+LPS vs. WT + LPS and Sh3^+/−+LPS vs. Sh3^+/−+PBS, not include in WT + LPS vs. WT + PBS.

Alms1-ps1

ALMS1, centrosome and basal body associated, pseudogene 1.

Atf3

ATF3 (activating transcription factor 3) is a member of the ATF/cAMP response element-binding (CREB) family and a stress-induced transcription factor that plays vital roles in neuroinflammatory response [88].

Ccl12

CCL12 (C-C motif chemokine ligand 12), also known as monocyte chemotactic protein 5 (MCP-5), promotes inflammation by attracting monocytes/ macrophages and upregulating pro-inflammatory cytokines [89].

Fas

Fas/FasL pathway plays a key role in immune homeostasis and leads to excessive neuroinflammation during excessive neuroinflammation [90].

Gm11681

long non-coding RNA.

Hspa1a

HSPA1A (also known as HSP70-1), HSPA1B (also known as HSP70-2), and HSPB1 (also known as HSP27) are all members of the heat shock protein (HSP) family that act as molecular chaperones helping in the proper folding of other proteins, protecting cells from stress, and modulating the immune response, thus influencing the neuroinflammation [91, 92].

Hspa1b

Hspb1

Oas1g

OAS1G (oligoadenylate synthetase 1g) is an important murine antiviral response factor, function through activating RNase L to degrade viral RNA in turn inhibiting viral replication and propagation [93].

Prok2

PROK2 (Prokineticin 2) is a secreted protein involved in the pathogenesis of several acute and chronic neurological diseases. It shows that PROK2 mediates neuronal cell deaths in traumatic brain injury via ferroptosis [94].