Fig. 2: Spatial similarity and subgroup consistency of CAP states in the placebo (PL) group.

A Spatial similarity matrix showing Pearson correlation coefficients between all six CAP-states derived from the PL group, demonstrating the distinct spatial characteristics of each state. B Spatial consistency matrices comparing each age subgroup (left: older adults; right: young adults) with the full PL group. These matrices reflect the degree of spatial correspondence between subgroup-derived CAP states and the PL group reference CAPs. Warmer colors indicate stronger spatial similarity (closer to 1.0), while cooler colors indicate dissimilarity (Pearson correlation coefficient r > 0.75).