Fig. 4: Multivariate associations between DNAm change and brain maturation.
From: A longitudinal DNA methylation atlas and its link to brain structure and mental health
a Schematic overview of the canonical correlation analysis (CCA) linking ΔDNAm in the 10 brain-related clusters to longitudinal brain structural change (ΔMRI: Δcortical thickness (CT), Δcortical surface area (SA), Δsubcortical volume). b–d Permutation-derived η² distributions (10,000 permutations) for each CCA model. e, f Canonical correlations for the first significant component. g, h Brain maps displaying regional loadings (CCA weights) for Δcortical thickness and Δsubcortical volume components; FDR-corrected P < 0.05. Warmer colours indicate regions that load positively, cooler colours indicate regions that load negatively.
