Fig. 5: Mediation models and cluster-specific DNAm associations with psychopathology.
From: A longitudinal DNA methylation atlas and its link to brain structure and mental health
a ΔSubstance use → ΔDNAm → ΔCortical Thickness: Indirect effects shown separately for cannabis use (left) and binge drinking (right), indicating full mediation. b Bidirectional models involving depressive symptoms: Left, ΔDepressive symptoms → ΔDNAm → ΔCortical Thickness; Right, ΔDNAm → ΔDepressive symptoms → ΔCortical Thickness. Path coefficients and P-values are shown. c, d Associations between DNAm levels in brain-related clusters and substance use at ages 14 and 19 (two-tailed PFDR < 0.05). e Significant associations of clusters C1 and C7 with depressive symptoms and negative psychotic symptom dimensions across adolescence (Pearson r; FDR-corrected two-tailed P-values). f Replication of C1 and C7 associations with depressive symptoms in PPMI (Pearson r; one-tailed P-values). g Associations of C1 and C7 with depressive symptoms and negative psychotic symptoms in IMAGEN after adjusting for depression or schizophrenia PRS, respectively (Pearson r; one-tailed P-values).
