Fig. 3: Subnetworks of the structural connectome associated with state and trait anxiety across healthy controls (HC) and depressed individuals without (MDD) and with comorbid anxiety disorders (MDD + ANX).

Node size represents the number of affected edges connected to each region (degree), with larger nodes indicating hub regions within the network. Nodes with the highest number of affected edges are labeled with their anatomical region names. Edge thickness reflects the effect size (F-statistic) for each connection, with thicker edges indicating stronger group differences. See online version for colored figures.