Fig. 4: Associations between posttraumatic stress disorder (PTSD) symptom severity and biomarkers of interest. | Neuropsychopharmacology

Fig. 4: Associations between posttraumatic stress disorder (PTSD) symptom severity and biomarkers of interest.

From: Identification of an intrusive-hypervigilant phenotype of posttraumatic stress symptoms with unique stress peptide and amygdala functional connectivity profiles

Fig. 4: Associations between posttraumatic stress disorder (PTSD) symptom severity and biomarkers of interest.The alternative text for this image may have been generated using AI.

A Pituitary adenylate cyclase-activating (PACAP) levels (square-root-transformed) were significantly associated with flashback severity (CAPS-5, item B3) but not with trauma-related intrusive memories (B1) or hypervigilance (E3). B–D Right centromedial amygdala (rCMA) FC with the parieto-occipital sulcus (POS), precuneus (Precun), and medial prefrontal cortex (mPFC) was positively associated with flashback severity. Weaker, trending associations were also observed between rCMA–mPFC connectivity and both intrusive memories and hypervigilance. CAPS-5: Clinician-Administered PTSD Scale for DSM-5.

Back to article page