Table 2 Fetal brain volume and cortical folding in SRI-exposed group vs unexposed controls.

From: Prenatal serotonin reuptake inhibitor exposure and maternal depression symptoms are associated with altered fetal brain and placental development

 

SRI-exposed (n = 62)

Unexposed (n = 120)

Difference (95% CI)

Adjusted Pa

Brain volume (cm3)

Cortical gray matter

63.52

65.09

–1.57 (–4.47 to 1.34)

0.38

White matter

97.82

100.75

–2.93 (–7.05 to 1.19)

0.24

Deep gray matter

15.14

15.50

–0.35 (–0.82 to 0.11)

0.24

Cerebellum

9.31

9.74

–0.42 (–0.90 to 0.05)

0.16

Brainstem

4.33

4.31

0.02 (–0.11 to 0.15)

0.79

Left hippocampus

0.45

0.53

-0.07 (–0.10 to –0.04)

0.0004

Right hippocampus

0.48

0.56

–0.08 (–0.11 to –0.05)

0.0004

Total brain volume

195.64

197.70

–2.07 (–8.48 to 4.34)

0.57

Cerebral cortical folding

Local gyrification index

1.24

1.28

–0.05 (–0.08 to –0.01)

0.03

Sulcal depth (mm)

1.65

1.69

–0.05 (–0.17 to 0.07)

0.53

Curvedness (mm-1)

0.21

0.24

–0.02 (–0.04 to –0.01)

0.0004

Surface area (cm2)

143.35

151.36

–8.01 (–13.74 to –2.27)

0.02

  1. Results of least squares means from analysis of covariance, controlling for gestational age at MRI scan, sex, maternal weight at MRI, and maternal depression score at MRI visit.
  2. aP values were adjusted for multiple testing based on the false discovery rate according to the Benjamini-Hochberg method.
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