Table 3 Area under curve (AUC)

From: Comparing olive oil and C4-dietary oil, a prodrug for the GPR119 agonist, 2-oleoyl glycerol, less energy intake of the latter is needed to stimulate incretin hormone secretion in overweight subjects with type 2 diabetes

 

Olive oil (a)

C4-Dietary oil (b)

Carrot (c)

P value

GLP-1 iAUC

645 ± 194

702 ± 97

7 ± 103

0.002a>c, b>c

GLP-1 tAUC

2,580 ± 204

2,247 ± 115

1,698 ± 115

0.0002a>c, b>c

GIP iAUC

4,338 ± 764

2,894 ± 601

266 ± 234

<0.0001a>c, b>c

GIP tAUC

6,891 ± 1068

4,300 ± 765

2,055 ± 243

<0.0001a>b, a>c, b>c

PYY iAUC

855 ± 1,009

1,402 ± 581

−612 ± 628

0.21

PYY tAUC

13,110 ± 1,526

11,430 ± 1,344

10,650 ± 1,269

0.02a>c

Glucose iAUC

61 ± 26

172 ± 77

148. ± 38

0.23

Glucose tAUC

1,791 ± 197

1,837 ± 213

1,927 ± 225

0.04c>a

C-peptide iAUC

66,050 ± 10,800

66,310 ± 9,302

49,130 ± 10,800

0.08

C-peptide tAUC

320,100 ± 20,830

314,000 ± 25,310

324,400 ± 24,840

0.78

Insulin iAUC

8,438 ± 2,222

10,690 ± 1,671

4,901 ± 1,883

0.02b>c

Insulin tAUC

32,430 ± 2,220

32,580 ± 3,451

33,430 ± 3,378

0.92

Glucagon iAUC

17 ± 104

420 ± 95

18 ± 83

0.005b>a, b>c

Glucagon tAUC

2,513 ± 278

2,556 ± 350

2,292 ± 343

0.11

CCK iAUC

103 ± 34

33 ± 37

−11 ± 22

 < 0.01a>c

CCK tAUC

252 ± 29

229 ± 27

151 ± 19

0.001a>c, b>c

Triglycerides iAUC

12.0 ± 6.8

−4.4 ± 3.9

−7.3 ± 6.0

0.013a>b, a>c

Triglycerides tAUC

240 ± 39

226 ± 27

210 ± 28

0.48

Acetaminophen tAUC

11.7 ± 1.0

13.4 ± 1.2

14.0 ± 1.2

0.02a<c

  1. Data are mean values ± SEM. All values in pM × min except glucose and triglycerides in mM × min and acetaminophen in µM × min. P values are calculated using repeated measurement ANOVA. P values ≤ 0.05 are considered statistically significant. Statistically significant differences between the three treatments are shown using the letters a, b and c, referring to the treatments
  2. CCK cholecystokinin, GIP glucose-dependent insulinotropic polypeptide (intact), GLP-1 glucagon-like peptide-1 (total), iAUC incremental area under curve, PYY peptide YY, tAUC total area under curve