Fig. 4: LocusZoom (LZ) plots for fat mass and lead SNP rs6664268 downstream of SEC16B against various LD backgrounds.
From: Genetic variants in SEC16B are associated with body composition in black South Africans
The strength of the LD with lead SNP (purple diamond) is indicated by r2 values, with each dot colour indicating an r2 value according to the key on the left-hand side of the LZ plot. A-The presence of variants that have a weaker correlation with the lead SNP is indicated by the blue dot (r2 = 0.4) and the yellow dot (r2 = 0.8) against an African LD background. B- The relationship of SNPs drawn against a European LD background, show that the cluster of associated SNPs are indistinguishable from one another, as reflected by their strong LD (red coloured dots) with the index SNP. C- illustrates an intermediate effect of correlated SNPs against an Asian LD background. The recombination hotspots are illustrated in blue peaks, with neighbouring genes shown beneath the plot
