Table 1 Metabolic parameters according to cut-off 155 mg/dL

From: Cardiometabolic importance of 1-h plasma glucose in obese subjects

 

<155 mg/dL (n = 1 177)

≥155 mg/dL (n = 1 262)

p-value

Adjusted for age and gender

Age (year)

38.3 ± 12.1

47.2 ± 11.6

0.001

NA

Gender male/female (%)

22.3/77.7

33.1/66.9

<0.001

NA

Weight (kg)

103.4 (92.5–117.4)

106.8 (95.0–121.8)

0.001

<0.001

BMI (kg/m2)

37.6 (34.5–41.2)

38.3 (34.8–41.9)

<0.001

<0.001

Waist (cm)

111.7 ± 14.8

117.5 ± 14.6

<0.001

<0.001

WHR

0.91 (0.84–1.00)

0.99 (0.90–1.08)

<0.001

<0.001

Fat mass (FM%)

51.1 (42.6–61.4)

50.8 (42.3–60.8)

NS

0.044

TAT (cm2)

791.3 ± 177.0

844.2 ± 176.0

<0.001

<0.001

VAT (cm2)

161.8 ± 77.8

217.6 ± 92.3

<0.001

<0.001

SAT (cm2)

630.0 ± 150.5

625.8 ± 146.9

NS

NS

VAT/SAT

0.27 ± 0.18

0.37 ± 0.22

<0.001

0.026

Anti hypertensive drugs; yes (%)

188 (16.0)

459 (36.4)

<0.001

<0.001

Lipid lowering drugs; yes (%)

48 (4.1)

167 (13.2)

<0.001

<0.001

Bp syst (mm-Hg)

130 (119–140)

134 (122–143)

<0.001

<0.001

Bp diast (mm-Hg)

80 (70–83)

80 (73–87)

<0.001

<0.001

Total cholesterol (mg/dL)

203 (178–226)

209 (183–236)

<0.001

0.036

HDL-C (mg/dL)

50 (41–61)

48 (40–59)

0.002

0.003

LDL-C (mg/dL)

122.0 (101.0–145.1)

126 (104–150.4)

0.003

NS

Fasting TG (mg/dL)

124.0 (92.0–164.8)

149.0 (112.0–204.0)

<0.001

0.001

MetS yes/no (%)

42.5/57.5

64.1/35.9

<0.001

<0.001

HOMA-IR

2.56 (1.72–3.82)

3.64 (2.28–5.77)

<0.001

<0.001

hs-CRP (mg/dL)

0.53 (0.24–1.03)

0.52 (0.25–1.03)

NS

<0.001

Microalbuminuria (24 h)(µg/min)

6.5 (4.1–11.0)

7.0 (4.7–14.0)

<0.001

NS

PAI-1 (ng/mL)

1.4 (0.5–2.7)

2.2 (1.0–4.0)

<0.001

<0.001

Fibrinogen

393.2 ± 84.3

389.7 ± 85.5

NS

NS

Gluc 0 (mg/dL)

80 (75–85)

90 (83–99)

<0.001

<0.001

Gluc 60 (mg/dL)

130 (116–142)

185 (168–211)

<0.001

<0.001

Gluc 120 (mg/dL)

114 (97–133)

155 (129–185)

<0.001

<0.001

NGT/IFG/IGT/IFG+IGT/T2DM (%)

962/7/197/4/7

412/30/471/116/233

  

(81.7/0.6/16.7/0.3/0.6)

(32.6/2.4/37.3/9.2/18.5)

<0.001

<0.001

AUC glucose

20,130 (18,315–22,099)

26,497 (23,773–30,169)

<0.001

<0.001

HbA1c (%)

5.4 (5.2–5.6)

5.7 (5.4–6.0)

<0.001

<0.001

HbA1c: NGT/prediabetes/T2DM (%)

446/97/0

278/254/63

<0.001

<0.001

(82.1/17.9/0.0)

(46.7/42.7/10.6)

Fasting insulin (mlU/L)

13.4 (8.9–20.0)

16.4 (11.0–25.0)

<0.001

<0.001

Fasting C-peptide (nmol/L)

0.86 (0.64–1.10)

1.05 (0.77–1.40)

<0.001

<0.001

  1. Data are expressed as mean ± SD or as median (Q1–Q3), if appropriate
  2. BMI body mass index, WHR waist-hip ratio, TAT total abdominal adipose tissue, VAT visceral abdominal adipose tissue, SAT subcutaneous abdominal adipose tissue, Bp diast diastolic blood pressure, Bp syst systolic blood pressure, HDL-C high-density lipoprotein-cholesterol, LDL-C low-density lipoprotein-cholesterol, TG triglycerides, HOMA-IR homeostasis model assessment insulin resistance, hs-CRP high-sensitive C-reactive protein, PAI-1 plasminogen activator inhibitor-1, Gluc plasma glucose, AUC area under the curve, NGT normal glucose tolerance, IFG impaired fasting glucose, IGT impaired glucose tolerance, T2DM type 2 diabetes mellitus, HbA1c hemoglobin A1c
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