Fig. 1: Plasma glucose concentrations following intragastric administration of 3 g (Trp-3) or 1.5 g (Trp-1.5) tryptophan, or control, in participants with type 2 diabetes. | Nutrition & Diabetes

Fig. 1: Plasma glucose concentrations following intragastric administration of 3 g (Trp-3) or 1.5 g (Trp-1.5) tryptophan, or control, in participants with type 2 diabetes.

From: Effects of intragastric administration of L-tryptophan on the glycaemic response to a nutrient drink in men with type 2 diabetes — impacts on gastric emptying, glucoregulatory hormones and glucose absorption

Fig. 1

After tryptophan alone (i.e. t = −31 to −1 min), there was no effect on fasting plasma glucose. Following the mixed-nutrient drink (i.e. t = 0 to 120 min), there was no effect on overall plasma glucose AUC−1 to 120 min. However, there was a significant treatment * time interaction for plasma glucose (P = 0.05); Plasma glucose after Trp-3 was lower from t = 15 to 30 min compared with control (*P < 0.05), and from t = 30 to 45 min compared with Trp-1.5 (**P < 0.05). Data are expressed as mean ± SEM; n = 12. Data were analysed using general linear model mixed-model analysis, with baseline as covariate, and repeated-measures ANOVA, and adjustments for multiple comparisons were made using Bonferroni correction.

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