Table 2 Outcome indices at baseline (T0) and follow-up visit after 6 months (T6) and the mean differences plus 95% CI between these visits in the normal glycemic and hyperglycemic groups of the study population.

From: Severe COVID-19 associated hyperglycemia is caused by beta cell dysfunction: a prospective cohort study

 

Normal glycemia

Hyperglycemia

Adjusted group differences

 

Mean ± SD

Mean ± SD

Mean difference (95% CI)

p

 

T0 (n = 26)

Insulinogenic index

2.78 ± 1.77

1.01 ± 0.51

−1.70 (−2.78, −0.63)

0.004

Insulin sensitivity index

3.47 ± 1.78

3.12 ± 1.23

−0.52 (−1.91, 0.86)

0.44

Disposition Index

8.40 ± 5.42

3.05 ± 1.79

−5.64 (−9.11, −2.16)

0.003

HOMA-beta

1.63 ± 1.07

2.00 ± 0.92

0.61 (−0.26, 1.47)

0.16

HOMA-IR

2.69 ± 1.87

4.03 ± 2.44

1.84 (−0.15, 3.84)

0.07

 

T6 (n = 26)

Insulinogenic index

1.35 ± 0.64

1.57 ± 2.28

0.52 (−1.32, 2.36)

0.56

Insulin sensitivity index

4.56 ± 1.27

4.52 ± 2.75

−0.62 (−2.67, 1.43)

0.53

Disposition Index

5.67 ± 1.98

4.45 ± 2.83

−1.11 (−3.47, 1.25)

0.34

HOMA-beta

1.20 ± 0.41

1.60 ± 1.24

0.62 (−0.35, 1.58)

0.20

HOMA-IR

2.04 ± 0.62

3.20 ± 2.83

1.59 (−0.59, 3.78)

0.14

 

ΔT6-T0 (n = 26)

 

Normal glycemia

Hyperglycemia

 

Mean difference (95% CI)

p

Mean difference (95% CI)

p

Insulinogenic index

−1.34 (−2.48, −0.19)

0.03

0.54 (−0.72, 1.79)

0.38

Insulin sensitivity index

1.02 (−0.17, 2.22)

0.08

1.84 (0.45, 3.24)

0.01

Disposition index

−2.39 (−6.73, 1.96)

0.23

1.05 (−0.33, 2.44)

0.12

HOMA-beta

−0.43 (−1.12, 0.27)

0.20

−0.48 (−0.90, −0.05)

0.03

HOMA-IR

−0.65 (−1.88, 0.59)

0.26

−0.99 (−1.90, −0.09)

0.03

  1. Data are shown as mean ± SD. Differences between the normal glycaemic and hyperglycaemic group are shown as mean difference ± 95% CI adjusted for age, sex, and BMI. P-values were derived from unpaired T-test.
  2. Differences over time between T6 and T0 were derived from paired T-test.
  3. CI confidence interval, HOMA-beta homeostasis model assessment of beta cell function, HOMA-IR homeostasis model assessment of insulin resistance, SD standard deviation, T0 baseline visit, T6 visit after six months, ΔT6-T0 change between T6 and T0.
  4. Bold values denote statistically significant p values.