Table 2 Hazard ratios with 95% confidence intervals for the association between urinary and dietary sucrose and diabetes incidence (n = 2996).

From: The mediating role of obesity on the prospective association between urinary sucrose and diabetes incidence in a sub-cohort of the EPIC-Norfolk

 

Model 1a

Model 2b

Model 2 + BMI

Model 2 + WC

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

Sucrose intake - FFQ

n

cases

 

Q1 (3.0–32.3 g)

n = 749

n = 26

1.00

1.00

1.00

1.00

Q2 (32.3–44.0 g)

n = 749

n = 28

1.07 (0.62, 1.82)

1.06 (0.61, 1.86)

1.15 (0.66, 2.01)

1.18 (0.68, 2.07)

Q3 (44.0–57.1 g)

n = 749

n = 23

0.85 (0.49, 1.50)

0.86 (0.45, 1.62)

1.00 (0.53, 1.89)

1.08 (0.57, 2.04)

Q4 (57.2–76.3 g)

n = 749

n = 20

0.72 (0.40, 1.30)

0.67 (0.30, 1.53)

0.82 (0.36, 1.84)

0.88 (0.39, 1.99)

pTrend

  

0.19

0.27

0.53

0.66

Per 50 g/d

n = 2996

n = 97

0.82 (0.56, 1.20)

0.81 (0.46, 1.42)

1.01 (0.58, 1.76)

1.03 (0.59, 1.81)

Sucrose intake - 7DD

n

cases

 

Q1 (0.5–28.1 g)

n = 749

n = 26

1.00

1.00

1.00

1.00

Q2 (28.1–38.4 g)

n = 749

n = 24

0.87 (0.50, 1.52)

0.92 (0.52, 1.63)

0.99 (0.55, 1.76)

1.03 (0.58, 1.85)

Q3 (38.5–49.5 g)

n = 749

n = 26

0.95 (0.55, 1.64)

1.00 (0.55, 1.80)

1.21 (0.67, 2.21)

1.29 (0.71, 2.35)

Q4 (49.5–65.9 g)

n = 749

n = 21

0.74 (0.41, 1.33)

0.75 (0.37, 1.51)

0.96 (0.47, 1.94)

0.95 (0.47, 1.91)

pTrend

  

0.35

0.46

1.00

0.95

Per 50 g/d

n = 2996

n = 97

0.67 (0.49, 0.92)

0.63 (0.43, 0.91)

0.76 (0.52, 1.10)

0.79 (0.55, 1.14)

Urinary sucrose

n

cases

 

Q1 (5.0–13.7 µM)

n = 749

n = 21

1.00

1.00

1.00

1.00

Q2 (13.7–32.6 µM)

n = 749

n = 23

1.08 (0.60, 2.00)

1.11 (0.61, 2.02)

1.07 (0.59, 1.94)

1.12 (0.62, 2.04)

Q3 (32.6–73.0 µM)

n = 749

n = 24

1.15 (0.64, 2.06)

1.18 (0.65, 2.12)

1.09 (0.61, 1.96)

1.11 (0.62, 2.00)

Q4 (73.3–499.9 µM)

n = 749

n = 29

1.37 (0.77, 2.41)

1.36 (0.77, 2.41)

1.21 (0.68, 2.14)

1.21 (0.68, 2.14)

pTrend

  

0.25

0.30

0.51

0.58

Per 100 µM

n = 2996

n = 97

1.14 (0.95, 1.37)

1.14 (0.95, 1.36)

1.08 (0.90, 1.30)

1.07 (0.90, 1.29)

  1. aAdjusted for age and sex.
  2. bAdjusted for age, sex, total energy, education level, smoking status, physical activity level, and family history of diabetes + height (for WC).
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