Fig. 5: KD-ameliorated hepatic steatosis is dependent on liver FGF21-KLB signaling.
From: Role of liver FGF21-KLB signaling in ketogenic diet-induced amelioration of hepatic steatosis
A Liver weight. B Liver triglyceride level. C Liver cholesterol level. D Hematoxylin and eosin and Oil Red O staining of the liver. E Liver Fgf21 expression. F Serum FGF21 level. G Expression of genes related to lipid metabolism in the liver. H Lipid metabolism related protein levels in the liver. I–K Immunofluorescence staining of albumin, ACC, FASN, and CPT1α in the liver. Green, ACC I, FASN J, and CPT1α K; red, albumin; blue, DAPI (magnification 200×, scale bar, 100 μm). FGF21, fibroblast growth factor 21; Fasn, fatty acid synthase; Acaca, acetyl-CoA carboxylase; Srebp1c, sterol regulatory element binding protein 1c; Pgc1a, peroxisome proliferator-activated receptor gamma coactivator 1-alpha; SCD1, stearyl-coenzyme A desaturase 1. n = 4-5 mice per group. *P < 0.05; **P < 0.01; ***P < 0.001.
