Fig. 1: No appreciable defect on glucose disposal in male or female lFgf21-/- mice when fed with LFD.

A Illustration of the animal experimental timeline. B–D Glucose level during tolerance test in adult male mice, Glucose tolerance test (GTT) at the age of 8 weeks (n = 6 for both Fgf21fl/fl and lFgf21-/-) (B). Pyruvate tolerance test (PTT) at the age of 10 weeks (n = 4) (C). Insulin tolerance test (ITT) at the age of 12 weeks (n = 4) (D). E–G Glucose level during GTT in adult female mice, GTT at the age of 8 weeks (n = 6 for Fgf21fl/fl, n = 5 for lFgf21-/-) (E). PTT at the age of 10 weeks (n = 3) (F). ITT at the age of 12 weeks (n = 3) (G). Body weight in both male (H) and female mice (I). Data are shown as the mean ± SEM.