Fig. 5: Dietary resveratrol intervention targets hepatic FGF21 and FGF21 signaling in HFHF diet-challenged Fgf21fl/fl mice. | Nutrition & Diabetes

Fig. 5: Dietary resveratrol intervention targets hepatic FGF21 and FGF21 signaling in HFHF diet-challenged Fgf21fl/fl mice.

From: Hepatic fibroblast growth factor 21 is required for curcumin or resveratrol in exerting their metabolic beneficial effect in male mice

Fig. 5: Dietary resveratrol intervention targets hepatic FGF21 and FGF21 signaling in HFHF diet-challenged Fgf21fl/fl mice.

A Illustration of the animal experimental timeline in Fgf21fl/fl mice [n = 4 for LFD group, and n = 6 for HFHF and HFR groups]. B Hepatic Fgf21 level in indicated group of mice. C Hepatic FGF21 protein levels. The bottom panel shows the densitometric analysis results. D Heat map shows comparison of selected FGF21-related genes among mice fed with LFD, HFHF and HFR diet. E–G qRT-PCR assessment on hepatic expression of indicated genes in LFD (n = 4), HFHF (n = 6) and HFR (n = 6) mice. Data are shown as the mean ± SEM. *p < 0.05, **p < 0.01 and ****p < 0.0001.

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