Fig. 3: Distinctive association of blood and metabolic biomarker profiles with four subtypes of CRAR metrics. | Nutrition & Diabetes

Fig. 3: Distinctive association of blood and metabolic biomarker profiles with four subtypes of CRAR metrics.

From: The role of circadian rest-activity rhythm for the link between 25-hydroxyvitamin D and type 2 diabetes: a cohort study

Fig. 3

Manhattan plots illustrating the results of linear regression for (A) Amplitude, B Acrophase, C Pseudo-F, and (D) Mesor, based on the analysis of 231 biomarkers from 39 categories of blood and metabolic biomarkers. The height of each point represents the negative logarithm of the P value of the t tests, with the color bar indicating the different biomarker categories. The black dashed line indicates the Bonferroni threshold for multiple comparisons (α = 0.05), and text annotations mark the top 15% of biomarkers exhibiting significant differences after Bonferroni correction (P < 0.05/231). All models were adjusted the same as the Model 4 in the Table 2.

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