Table 1 Demographic criteria and biochemical parameters in the studied groups.
Control (60) | DM (70) | DN (70) | Test statistic | p | |
|---|---|---|---|---|---|
Age (years) | 40 (32–45) | 44 (35–48) | 42 (36-47.25) | 2.202 | 0.113 |
Sex | 4.738 | 0.094 | |||
Male | 40 (34.2%) | 34 (29.1%) | 43 (36.8%) | ||
Female | 20 (24.1%) | 36 (43.4%) | 27 (32.5%) | ||
BMI (kg/m2) | 24 (21-26.23) | 33 (30–36)a | 22 (19-23.5)a,b | 137.860 | <0.0001 |
F_Glucose (mg/dL) | 92 (75–97) | 164 (138.5 -239)a | 267.5 (205.75-302.5)a,b | 138.184 | <0.0001 |
HbA1c (%) | 5.1 (4.5–5.4) | 7.2 (6.7–8.23)a | 8.5 (8.4–8.9)a,b | 145.343 | <0.0001 |
Creatinine (mg/dL) | 0.8 (0.7–1.06) | 1.0 (0.7–1.2) | 3.22 (2.8–4.13)a,b | 137.690 | <0.0001 |
Albuminuria (mg/day) | 4.15 (3.8–4.4) | 5.5 (3.11–7.73) | 58 (45–75)a,b | 139.999 | <0.0001 |
GAS6 (pg/mL) | 251.6 (222.8–315.6) | 211 (184.75–264)a | 104.7 (84.03–125.33)a,b | 132.857 | <0.0001 |
AXL (pg/mL) | 286.95 (241.7–339.18) | 220.95 (166.15–259.35)a | 94.2 (50.98–137.45)a,b | 131.363 | <0.0001 |
GAS6-AS1 (fold change) | 1.0 (0.5–1.48) | 1.3 (0.23–2.15) | 1.6 (0.78–2.14)a | 8.680 | 0.013 |
GAS6-DT (fold change) | 1.02 (0.26–2.35) | 7.52 (4.45–9.03)a | 16.54 (9.32–35.99)a,b | 151.317 | <0.0001 |
