Table 2 Agreement level between GAS6-related parameters and conventional parameters [(HbA1c and fasting glucose) as diagnostic tests for diabetes mellitus, and (microalbuminuria and creatinine) as diagnostic tests for diabetic nephropathy].
Conventional parameters: microalbuminuria or creatinine (1.2 mg/dL) | Kappa | Conventional parameters: HbA1c = 5.7% or F_Glu = 100 mg/dL | Kappa | ||||||
|---|---|---|---|---|---|---|---|---|---|
Normal kidney (130) | Nephropathy (70) | Diabetic (140) | Non-diabetic (60) | ||||||
GAS6 (cut-off: <174.65 pg/mL) | Normal kidney | 117 (90%) | 0 (0%) | 0.863 | GAS6 (cut-off: <213 pg/mL) | Diabetic | 106 (75.7%) | 7 (11.7%) | 0.568 |
Nephropathy | 13 (10%) | 70 (100%) | Non-diabetic | 34 (24.3%) | 53 (88.3%) | ||||
Fisher’s Exact, p < 0.0001 | χ2 = 70.10, p < 0.0001 | ||||||||
AXL (cut-off: <149.65 pg/mL) | Normal kidney | 119 (91.5%) | 9 (12.9%) | 0.782 | AXL (cut-off: <231.6 pg/mL) | Diabetic | 112 (80%) | 12 (20%) | 0.558 |
Nephropathy | 11 (8.5%) | 61 (87.1%) | Non-diabetic | 28 (20%) | 48 (80%) | ||||
χ2 = 122.257, p < 0.0001 | χ2 = 64.177, p < 0.0001 | ||||||||
Combined GAS6/AXL (both cut-offs) | Normal kidney | 129 (99.2%) | 9 (12.9%) | 0.887 | Combined GAS6/AXL (both cut-offs) | Diabetic | 91 (65%) | 2 (3.3%) | 0.504 |
Nephropathy | 1 (0.8%) | 61 (87.1%) | Non-diabetic | 49 (35%) | 58 (96.7%) | ||||
Fisher’s Exact, p < 0.0001 | Fisher’s Exact, p < 0.0001 | ||||||||
GAS6-AS1 (cut-off: >1.203 folds) | Normal kidney | 69 (53.1%) | 26 (37.1%) | 0.143 | GAS6-AS1 (cut-off: >1.203 folds) | Diabetic | 83 (59.3%) | 22 (36.7%) | 0.194 |
Nephropathy | 61 (46.9%) | 44 (62.9%) | Non-diabetic | 57 (40.7%) | 38 (63.3%) | ||||
χ2 = 4.632, p = 0.031 | χ2 = 8.617, p = 0.0003 | ||||||||
GAS6-DT (cut-off: >11.21 folds) | Normal kidney | 130 (100%) | 20 (28.6%) | 0.765 | GAS6-DT (cut-off: >3.29 folds) | Diabetic | 138 (98.6%) | 2 (3.3%) | 0.952 |
Nephropathy | 0 (0%) | 50 (71.4%) | Non-diabetic | 2 (1.4%) | 58 (96.7%) | ||||
Fisher’s Exact, p < 0.0001 | Fisher’s Exact, p < 0.0001 | ||||||||
