Table 3 Overview of adverse events by grade.
Adverse event category | Adverse event | Any grade (%) | Grade 1 (%) | Grade 2 (%) | Grade 3 (%) | Grade 4 (%) |
|---|---|---|---|---|---|---|
Blood system disorders | ||||||
Leukopenia/neutropenia | 31 (51.67%) | 14 (23.33%) | 10 (16.67%) | 6 (10%) | 1 (1.67%) | |
Thrombopenia | 6 (10%) | 4 (6.67%) | 2 (3.33%) | 0 | 0 | |
Anemia | 31 (51.67%) | 27 (45%) | 4 (6.67%) | 0 | 0 | |
Gastrointestinal disorders | ||||||
Nausea | 27 (45%) | 18 (30%) | 7 (11.67%) | 2 (3.33%) | 0 | |
Vomiting | 3 (5%) | 3 (5%) | 0 | 0 | 0 | |
Diarrhea | 9 (15%) | 5 (8.33%) | 4 (6.67%) | 0 | 0 | |
General disorders | ||||||
Fatigue | 35 (58.33%) | 32 (53.33%) | 3 (5%) | 0 | 0 | |
Fever | 7 (11.67%) | 7 (11.67%) | 0 | 0 | 0 | |
Muscle soreness | 44 (73.33%) | 37 (61.67%) | 7 (11.67%) | 0 | 0 | |
Respiratory disorders | ||||||
Pneumonitis | 3 (5%) | 1 (1.67%) | 1 (1.67%) | 1 (1.67%) | 0 | |
Nervous system disorders | ||||||
Peripheral sensory neuropathy | 31 (51.67%) | 27 (45%) | 4 (6.67%) | 0 | 0 | |
Metabolism and nutrition disorders | ||||||
Anorexia | 24 (40%) | 24 (40%) | 0 | 0 | 0 | |
Hyperglycemia | 14 (23.33%) | 13 (21.67%) | 0 | 1 (1.67%) | 0 | |
Skin disorders | ||||||
Alopecia | 56 (93.33%) | 32 (53.33%) | 24 (40%) | 0 | 0 | |
Rash | 22 (36.67%) | 15 (25%) | 6 (10%) | 1 (1.67%) | 0 | |
Endocrine disorders | ||||||
Hyper/hypothyroidism | 5 (8.33%) | 4 (6.67%) | 1 (1.67%) | 0 | 0 | |
Investigations | ||||||
AST increased | 17 (28.33%) | 12 (20%) | 4 (6.67%) | 1 (1.67%) | 0 | |
ALT Increased | 15 (25%) | 12 (20%) | 2 (3.33%) | 1 (1.67%) | 0 | |
Creatinine Increased | 1 (1.67%) | 1(1.67%) | 0 | 0 | 0 | |
Serum lipase increased | 8 (13.33%) | 8 (13.33%) | 0 | 0 | 0 | |
Electrolyte abnormalities | 5 (8.33%) | 4 (6.67%) | 1 (1.67%) | 0 | 0 | |
ALP increased | 3 (5%) | 3 (5%) | 0 | 0 | 0 | |
GGT increased | 7 (11.67%) | 5 (8.33%) | 2 (3.33%) | 0 | 0 | |
Creatine kinase increased | 5 (8.33%) | 5 (8.33%) | 0 | 0 | 0 | |
BNP increased | 10 (16.67%) | 10 (16.67%) | 0 | 0 | 0 |
